منابع مشابه
Deciphering the Pathogenesis of NSAID-Enteropathy
1 Using Proton Pump Inhibitors and a Hydrogen Sulfide-Releasing NSAID 2 3 Rory W. Blackler, Giada De Palma, Anna Manko, Gabriela J. Da Silva, 4 Kyle L. Flannigan, Premysl Bercik, Michael G. Surette, 5 Andre G. Buret & John L. Wallace 6 *co-first authors of the paper 7 Department of Medicine, McMaster University, 8 Hamilton, Ontario, L8S 4L8, Canada 9 Department of Physiology & Pharmacology, Uni...
متن کاملDeciphering the pathogenesis of NSAID enteropathy using proton pump inhibitors and a hydrogen sulfide-releasing NSAID.
The small intestine is a significant site of ulceration and bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The pathogenesis is poorly understood. The present study explored the roles of bile, bacteria, and enterohepatic circulation to NSAID enteropathy, using both a conventional NSAID (naproxen) and a gastrointestinal-safe naproxen derivative (ATB-346), as well as proton pum...
متن کاملNSAID-induced enteropathy: are the currently available selective COX-2 inhibitors all the same?
Nonsteroidal anti-inflammatory drugs (NSAIDs) can induce intestinal mucosal damage, but the underlying mechanisms remain poorly understood. The present study investigated the effects of celecoxib, etoricoxib, indomethacin, and diclofenac on small bowel integrity in rats. Male rats were treated orally with test drugs for 14 days. Animals were processed for assessment of blood hemoglobin levels a...
متن کاملEnantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat.
BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage by a non-prostaglandin (PG) dependent "topical" action and by inhibiting cyclooxygenase. AIMS To discriminate between these two effects by studying some key pathophysiological steps in NSAID enteropathy following administration of (R)- and (S)-flurbiprofen, the racemic mixture, and an uncoupler, dinitrophe...
متن کاملNSAID-Induced Enteropathy: Are the Currently Available Selective COX-2 Inhibitors All the Same? s
Nonsteroidal anti-inflammatory drugs (NSAIDs) can induce intestinal mucosal damage, but the underlying mechanisms remain poorly understood. The present study investigated the effects of celecoxib, etoricoxib, indomethacin, and diclofenac on small bowel integrity in rats. Male rats were treated orally with test drugs for 14 days. Animals were processed for assessment of blood hemoglobin levels a...
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ژورنال
عنوان ژورنال: Terapevticheskii arkhiv
سال: 2020
ISSN: 2309-5342,0040-3660
DOI: 10.26442/00403660.2020.02.000453